Yes, it is generally safe to have sex during the 16th week of pregnancy. By this time, most women have passed the first trimester and are experiencing fewer symptoms such as morning sickness and fatigue. However, it is important to consult with your healthcare provider before engaging in sexual activity, as every pregnancy is unique and there may be specific factors that need to be considered. In most cases, if you have a healthy pregnancy with no complications, there should be no reason to avoid sex at this stage. It is important to communicate openly with your partner about any concerns or discomfort you may have during intercourse. If you experience any unusual symptoms such as bleeding or pain after having sex, contact your healthcare provider immediately for further evaluation and guidance.